MigreLief Original Formula

$13.92$167.04

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SKU: 22/28 UPC: 8-55586-00022-3

Summary

The only multi-patented, physician recommended nutritional migraine supplement for either men, women or children age 12 and older, who suffer from chronic migraines. MigreLief contains ingredients proven to make a difference.

Normal cerebrovascular tone and function is disrupted in people who have migraines. Nutritional deficiencies, inflammation and vasospasm can independently and together contribute to migraine occurrence, frequency and intensity. MigreLief’s patented “Triple Therapy” ingredients combat migraines nutritionally at the cellular level.

Puracol, MigreLief’s proprietary blend of two unique Feverfew sources, Magnesium from two sources and high dose, highly absorbable Riboflavin (Vitamin B-2) have all independently been shown to be of significant therapeutic benefit to chronic migraine sufferers.

To learn more about how these “Triple Therapy” ingredients actually work, please click our product information tab.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Product Information

MigreLief (formerly MigreHealth and MigreLieve) is a patented combination (patents 6,068,999 and 6,500,450) of 3 natural ingredients, which multiple, double-blind, placebo controlled clinical studies published in top medical journals have shown to be nutritionally beneficial to migraine sufferers. MigreLief contains:

Magnesium (citrate and oxide) 360mg/day
Riboflavin (Vitamin B2) 400mg/day
Puracol™ Feverfew (proprietary extract + whole leaf) 100mg/day

In addition to high dose riboflavin, MigreLief contains a specific combination of two forms of magnesium. Puracol represents proprietary feverfew science specific to MigreLief as well. While extracts of feverfew can maximize certain phytochemicals found in the whole plant, like parthenolides, the extraction process can also remove other naturally occurring phytochemicals that may be required for maximum efficacy. The puracol technology corrects this problem by simultaneously maximizing parthenolide levels while maintaining the full spectrum of all the other naturally occurring compounds found in the whole plant.

Research studies show that almost half of all migraine sufferers have low blood levels of Magnesium, which is critical in controlling vasospasms (the contraction and dilation of blood vessels in the brain which occurs during migraines).

Migraine sufferers also suffer mitochondrial energy deficiencies, which Riboflavin (Vitamin B2) can improve when given in high dosages.

The plant material Feverfew has been shown to reduce platelet aggregation, which can lead to vasoconstriction. All 3 ingredients have been recommended for years by many doctors and top headache specialists based on the clinical studies behind them.

MigreLief combines all three of these ingredients into one convenient formula. So, with MigreLief, you need only one product (instead of three separate products), and you take only two tablets per day, versus 4 to 10 tablets per day if taken separately. Plus, MigreLief’s Puracol Feverfew contains high levels of parthenolides and other dietary ingredients.

See links to the top right for more product information.

Two tablets provide:
Puracol Feverfew(Tanacetum parthenium) – 100 mg.
Magnesium (Citrate/Oxide 1:1) – 360mg, which is 90% of U.S. RDA*
Riboflavin (Vitamin B2) – 400 mg, which is 23,525% of U.S. RDA*

*Percentage of U.S. recommended daily allowance

Contains no yeast, milk, corn, wheat, gluten, soy, sodium, salt, sugar, flavorings, preservatives, artificial colors.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredients

Magnesium

Magnesium is a nutritional supplement with numerous effects that support cerebrovascular tone. These include: 1) inhibition of platelet aggregation; 2) interference with synthesis, release, and action of inflammatory mediators; 3) direct alterations of cerebrovascular tone; 4) inhibition of vasospasm; and 5) stabilization of cell membranes. Some migraine sufferers with poor cerebrovascular tone have been found to have low brain levels of magnesium. Recommended daily dosages of magnesium typically range from 200 to 600 mg to compensate for this deficiency, far above what’s found in most multi-vitamins. Several double blind placebo controlled studies have demonstrated that oral magnesium is of nutritional benefit to migraine sufferers both adults and children. (11-16)

Riboflavin

Riboflavin (vitamin B-2) is a precursor of flavin adenine dinucleotide (FAD). This coenzyme is an important component of the electron-transport chain. A deficiency of mitrochondrial energy reserves has been observed in some persons exhibiting poor cerebrovascular tone. This defect may theoretically be corrected by a compound such as riboflavin that improves the activity of the electron-transport chain. MigreLief provides 400mg of Riboflavin, which is significantly higher than most multi-vitamins or B-complex products. Multiple studies have demonstrated that high dose riboflavin is of nutritional benefit to both adults and children who have migraines. (17-20)

Feverfew

Puracol Feverfew is unique to Migrelief. Commonly recommended for its ability to support cerebrovascular tone, feverfew (Tanacetum Parthenium) is rich in compounds known as sesquiterpene lactones. One of the more important of these compounds may be parthenolide, which represents 85% of the sesquiterpene lactone content in feverfew. Some scientific studies indicate that while parthenolide may be important there may very well be other phytochemicals in feverfew that are as of yet unidentified and play a role in its effectiveness. Some studies of extracts of feverfew containing parthenolide yielded no significant benefits. This led researchers to believe that certain of the unidentified phytochemicals may have been left behind during the extraction process. The ideal solution would be a non extracted feverfew product that naturally contained high levels of parthenolide and kept all of the other naturally occurring phytochemicals as well. Thus Puracol Feverfew, AKESO HEALTH SCIENCE’S proprietary non extracted plant source for feverfew with high levels of naturally occurring parthenolide was developed. Puracol Feverfew is just one of the reasons for the superior efficacy of MigreLief, which delivers optimal dosages of parthenolide. Scientific studies have found parthenolide inhibits platelet aggregation and the release of serotonin from platelets and polymorphonuclear leukocyte granules.* It has also been shown to inhibit pro-inflammatory prostaglandin synthesis and the release of arachadonic acid. Each of these phenomena is associated with migraines. European studies have shown the benefits of feverfew on long-term cerebrovasular tone in multiple human studies. (1-10)

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Take 1 tablet twice daily.

MigreLief is designed to provide benefits within the 90 day build up period.
Continue daily use if you notice benefits.

MigreLief is drug-free. No prescription necessary.

Like most dietary supplements, use of MigreLief should be discontinued one week before surgery to reduce the risk of excessive bleeding.

Please note: Not for use during pregnancy, during lactation or by children under 2 years of age.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Side Effects

Potential side effects, though rare, can be:

  1. An individual being allergic to any of the ingredients in MigreLief. If you are allergic to any of the ingredients, cease taking the product.
  2. Some individuals may experience transient diarrhea when ingesting magnesium.
  3. Some individuals can experience gastro-intestinal upset when taking dietary supplements.
  4. Riboflavin (Vitamin B-2) can cause urine to become bright yellow. This is normal and harmless.
  5. Though rare, some people can feel achy, tired and experience a headache if they abruptly stop taking feverfew. It is recommended that you taper off gradually, cutting the dose down to one daily for a week, then down to one every other day for a week, and then stop.
  6. Like most dietary supplements, use of MigreLief should be discontinued one week before surgery to reduce the risk of excessive bleeding.

Warning: Not for use during pregnancy, during lactation or by children under 2 years of age.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References

  1. Brown D, Gaby A, Reichert R. Clinical Applications of Natural Medicine–Migraine. NPRC Condition-Specific Monograph Series, 1997.
  2. Feverfew. Lawrence Review of Natural Products, September 1994.
  3. Awang DVC. Herbal Medicine, Feverfew. Canadian Pharm J 1989; 122:266-70.
  4. Heptinstall S, Awang DVC, Dawson BA, et al. Parthenolide Content and Bioactivity of Feverfew (Tanacetum parthenium). Estimation of Commercial and Authenticated Feverfew Products. J Pharm Pharmacol 1992; 44:391-5.
  5. Pugh WJ, Sambo K. Prostaglandin Synthetase Inhibitors in Feverfew. J Phrm Pharmacol 1988; 40-743-5
  6. Heptinstall S, White A, Williamson L, Mitchell JRA. Extracts of Feverfew Inhibit Granule Secretion in Blood Platelets and Polymophonuclear Leukocytes. Lancet 1985; i:1071-4.
  7. Makheja AN, Bailey JM. A Platelet Phospholipase Inhibitor from the Medicinal Herb Feverfew (Tanacetum parthenium). Prostagland Leukotrienes Med 1982;8:653-60.
  8. Sumner H, Salan U, Knight DW, Hoult JRS. Inhibition of 5-Lipoxygenase and Cyclo-oxygenase in Leukocytes by Feverfew. Biochem Pharmacol 1992;43:2313-20.
  9. Johnson ES, Kadam NP, Hylands DM, Hylands PF. Efficacy of Feverfew As prophylactic Treatment of Migraine. British Med J 1985; 291:569-73.
  10. Murphy JJ. Heptinstall S, Mitchell JRA. Randomized Double-Blind Placebo-Controlled Trial of Feverfew in Migraine Prevention. Lancet 1988; ii:189-92.
  11. Altura BM. Calcium Antagonist Properties of Magnesium: Implications for Anti-migraine Actions. Magnesium 1985; 4:169-75.
  12. Ramadan NM, Halvorson H, Vande-Linde A, et al. Low Brain Magnesium in Migraine. Headache 1989; 29:590-93.
  13. Weaver K. Magnesium and Migraine. Headache 1990; 30:168.
  14. Faccinetti F, Sances G, Borella P, et al. Magnesium Prophylaxis of Menstrual Migraine: Effects on Intra-cellular Magnesium. Headache 1991; 31:298-304.
  15. Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of Migraine with Oral Magnesium: Results from a Prospective, Multi-Center, Placebo-Controlled and Double-Blind Randomized Study. Cephalalgia 1996; 16:257-63.
  16. Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the Prophylaxis of Migraine Cephalalgia 1996;16;436-40
  17. Schoenen J, Lenaerts M, Bastings E. High-dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study. Cephalalgia 1994l14:328-9
  18. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomised controlled trial. Neurology 1998; 50: 46670.
  19. Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhaupl KM, Arnold G. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol. 2004 Jul;11(7):475-7.
  20. Maria Condò, Annio Posar, Annalisa Arbizzani and Antonia Parmeggiani Riboflavin prophylaxis in pediatric and adolescent migraine. The Journal of Headache and Pain: Volume 10, Number 5 / October, 2009

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