SKU: 62/68 UPC: 8-55586-000692-9


In addition to the “Triple Therapy” ingredients of Puracol™ feverfew, riboflavin and magnesium found in Original MigreLief, five additional clinically documented ingredients have been added to MigreLief+M: A special standardized Chasteberry extract, L-Theanine (a specially isolated component from green tea), high dose biotin and high dose pyridoxine hydrochloride (Vitamin B-6) and Chromium Picolinate.  All five of these additional ingredients have been shown in human clinical studies to balance hormone and blood sugar fluctuations (which occur around menstruation and may cause migraines in susceptible women), and/or manage the symptoms of PMS and PCOS.

Researchers and Physicians who specialize in female related health issues and complaints know that the “Troublesome Twosome” of monthly fluctuations in female hormones and blood sugar are major factors in causing:

  • Migraines
  • PMS symptoms
    • Breast pain
    • Cravings
    • Bloating
    • Depression
    • Irritability
    • Difficulty concentrating
  • Weight Gain
  • Acne
  • Irregular menstrual cycles
  • Infertility

The ingredients in MigreLief+M have been shown to help women with these hormone related issues by helping to maintain normal blood sugar and hormone levels.

If you suffer from one or more of the troublesome feminine health issues listed above, MigreLief+M is for you.*

To learn more about how these ingredients work and the benefit for migraine sufferers, as well as PMS and PCOS sufferers, please click the Product Information tab.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Product information

MigreLief+M contains the same three patented (patents 6,068,999 and 6,500,450) ingredients in Original MigreLief plus five additional ingredients to help women maintain normal blood sugar and hormone levels:

High dose Riboflavin (Vitamin B-2, 400 mg/day)
Puracol Feverfew (100 mg/day)
Magnesium (citrate/oxide, 360mg/day)
Chasteberry extract (275 mg/day)
L-Theanine (100 mg/day)
D-Biotin (15 mg/day)
Pyridoxine Hydrochloride (vitamin B-6, 100 mg/day)
Chromium Picolinate (1,000 mcg/day)

MigreLief+M combines all eight ingredients into one convenient formula. So, with MigreLief+M, you need only one product (instead of eight separate products), and you take only two tablets per day, versus 8 to 10 tablets per day if taken separately. Plus, MigreLief contains Puracol™ Feverfew a proprietary combination of whole leaf feverfew that contains a broad spectrum of naturally occurring phytochemicals and a feverfew extract containing high levels of parthenolides.

MigreLief+M is drug-free. No prescription needed.

This product is not intended to diagnose, treat, cure or prevent any disease.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.



Research studies show that almost half of all migraine sufferers have low blood levels of magnesium – which is critical in controlling vasospasms (the contraction and dilation of blood vessels in the brain which occurs during migraines).

Magnesium is a nutritional supplement with numerous effects that support cerebrovascular tone.  These include: 1) inhibition of platelet aggregation; 2) interference with synthesis, release, and action of inflammatory mediators; 3) direct alterations of cerebrovascular tone; 4) inhibition of vasospasm; and 5) stabilization of cell membranes. Some migraine sufferers with poor cerebrovascular tone have been found to have low brain levels of magnesium.(11-16) Recommended daily dosages of magnesium typically range from 400 to 600 mg to compensate for this deficiency — far above what’s found in most multi-vitamins.

Riboflavin (Vitamin B-2)

Riboflavin (vitamin B-2) is a precursor of flavin adenine dinucleotide (FAD). This coenzyme is an important component of the electron-transport chain. A deficiency of mitrochondrial energy reserves has been observed in some persons exhibiting poor cerebrovascular tone. This defect may theoretically be corrected by a compound such as riboflavin that improves the activity of the electron-transport chain. MigreLief provides 400mg of Riboflavin — significantly higher than most multi-vitamins or B-complex products.
Riboflavin at the dose contained in MigreLief+M has been shown to significantly reduce the frequency and intensity of migraines both in adults and children. (17-20)

Feverfew (Tanacetum parthenium)

Commonly recommended for its ability to support cerebrovascular tone, feverfew (Tanacetum parthenium) is rich in compounds known as sesquiterpene lactones. One of the more important of these compounds may be parthenolide, which represents 85% of the sesquiterpene lactone content in feverfew. Some scientific studies indicate that while parthenolide may be important there may very well be other phytochemicals in feverfew that are as of yet unidentified and play a role in its effectiveness for migraines.(1-10) Some studies of extracts of feverfew containing parthenolide yielded no significant benefits. This led researchers to believe that certain of the unidentified phytochemicals may have been left behind during the extraction process. The ideal solution would be a non extracted feverfew product that naturally contained high levels of parthenolide and kept all of the other naturally occurring phytochemicals as well. Thus, Puracol Feverfew (AKESO HEALTH SCIENCE’S proprietary non extracted plant source for feverfew) with high levels of naturally occurring parthenolide was developed. Puracol Feverfew, is just one of the reasons for the superior efficacy of MigreLief which delivers optimal dosages of parthenolide.

Chasteberry Standardized Extract

The specific dose and extract of Chasteberry used in MigreLief+M have been shown in numerous studies to establish balance of female hormones as well as testosterone, that can fluctuate greatly around the time of menstruation.

Reestablishing this hormonal balance will either eliminate or significantly reduce many of the symptoms described in the product summary.

The ability of Chasteberry extract to truly “balance hormones” is documented and very impressive.

For example, women who have their periods too frequently (polymennorhia), every 20 days for example, Chasteberry extract can lengthen the time between periods to a more acceptable 25-28 days.

On the other hand, women who have their periods infrequently (oligomennorhia), say every 40-60 days, Chasteberry extract can bring them back to a regular 25-28 day cycle.

Additionally, for women who have very painful periods, or who bleed too heavily during menstruation, this impressive extract can reduce both the pain and excessive bleeding.

As you will later read, Chasteberry extract is extremely effective at alleviating both symptoms of PMS and PCOS.

Finally, for women starting to suffer from menopausal symptoms (also a hormonal imbalance) Chasteberry extract has been shown to be effective as well.

A double-blinded, German study of 178 women given Chasteberry extract examined its effects on PMS symptoms. The researchers found significant improvement of irritability, mood alteration, anger, headache, breast pain and bloating in the patients taking the active Chasteberry versus placebo. The researchers stated that Chasteberry is an effective and well tolerated treatment for the relief of PMS symptoms. (21)

In another study of 117 women with both menstrual cycle issue and/or PMS, who were suffering with acne, administration of Chasteberry extract significantly improved acne after 8 weeks, and over 70% of patients were acne free after 3 months. A second study done many years later, confirmed these results.(22,23)

A study of 126 women who were suffering with menstrual disorders (where either cycles were too short, too long or whose bleeding was excessive), found that treatment with Chasteberry extract administered over 3-4 months, corrected or significantly improved these issues in over 90% of the women. (24)

Women who suffer from PCOS can experience infertility, painful periods, no periods, hairloss and acne. These women often have excessive levels of testosterone as well. Chasteberry extract has been shown to lower testosterone levels, restore or improve hair loss, and resolve acne issues in many of these women.(25)

Who shouldn’t use Chasteberry extract?

It is theoretically possible, that the estrogen levels of women on birth control pills may escalate with the use of Chasteberry extract (Vitex) and render the birth control pills less effective. This has not been shown to happen in any published studies, but is “theoretically” possible.

Women who are on birth control pills should discuss the use of chasteberry with their physician. As previously mentioned, birth control pills can either worsen or improve migraines in certain women.

Because Chasteberry extract helps with migraines by normalizing estrogen and progesterone production, it should not be used by women who have breast cancer or other estrogen related diseases or conditions.

It is thought that Chasteberry extract can enhance dopamine levels which can help with increased libido, and this is a favorable effect. But, for patients taking dopamine enhancing drugs like levodopa for Parkinsons, Chasteberry extract may theoretically increase the effect of these drugs and should be discussed with your physician prior to use.


Fluctuations in blood sugar are strongly related to the occurrence of migraines, the symptoms of PMS and PCOS.
Though biotin supplementation is recommended by many healthcare practitioners and nutritionists for healthy nails and hair, the amount of biotin that is required to stabilize blood sugar levels is 50-100 times higher and not found in off-the-shelf supplements or multi-vitamins.

Being water a water soluble B-vitamin not only is biotin safe at these levels but it may be heart healthy as well because it lowers triglycerides which can contribute to heart disease.

It is at this higher level that biotin may work with Chasteberry extract to reduce or eliminate the PMS symptoms previously mentioned, as well as weight gain, acne, hair loss and of course, migraines.

Low blood sugar is frequently associated with migraine attacks. The lower the blood sugar level, the more severe the attack can be. Often blood sugar levels drop, not because we haven’t consumed sugar, but because we initially didn’t release enough insulin to lower it or we don’t respond well to the insulin we produce.

This makes the body release even more insulin causing blood sugar levels to drop precipitously. This large fluctuation in both insulin and blood sugar levels can contribute to you developing a migraine.

Biotin at the doses included in MigreLief+M has been shown in numerous studies to help regulate both insulin and blood sugar levels, even in diabetics. (26,27)


Pyridoxine Hydrochloride – Vitamin B-6


Multiple human studies (listed below) in almost 1000 women, have shown that vitamin B-6, at the dose found in MigreLief+M, helps to alleviate PMS symptoms of breast pain, irritability, depression, cravings and bloating.(28-34)



Theanine is an amino acid found in green tea that is very calming and can lessen the symptoms of PMS.

A study in Japan showed that taking the dose of theanine found in MigreLief+M increased alpha waves in the brain. This is an effect similar to what occurs when one relaxes in a hot bath or gets a massage, but does not cause drowsiness.

These studies also demonstrate that theanine may reduce mental and physical stress and improve both cognition and mood, all of which are important benefits for women suffering with PMS. (35-37).

15- Gomez-Ramirez M; Higgins, BA; Rycroft, JA; Owen, GN; Mahoney, J; Shpaner, M; Foxe, JJ (2007). “The Deployment of Intersensory Selective Attention: A High-density Electrical Mapping Study of the Effects of Theanine”. Clin Neuropharmacol 30 (1): 25–38.

16- Kimura K, Ozeki M, Juneja L, Ohira H (2007). “L-Theanine reduces psychological and physiological stress responses”. Biol Psychol 74 (1): 39–45.

17- Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB (2008). “The effects of l-theanine, caffeine and their combination on cognition and mood”. Biol Psychol 77 (2): 113–22.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Take 1 tablet twice daily.

MigreLief+M is designed to provide benefits within the 90 day build up period. To maintain benefits achieved, continue using daily.

MigreLief+M is drug-free. No prescription necessary.

MigreLief+M is intended for use by menstruating females, or pre-menopausal/menopausal women who suffer from chronic migraines associated with their periods or menopause and/or symptoms of PMS and symptoms of PCOS.

Take one caplet twice a day for 90 days during the build-up period. To maintain benefits achieved, continue taking daily.

Together, the ingredients in MigreLief+M will control hormonal and blood sugar fluctuations, that when uncontrolled can lead to:

  1. Chronic Migraines
  2. PMS and PCOS* symptoms of:
    • Bloating
    • Cravings
    • Breast pain
    • Irritability
    • Depression
    • Anxiety
    • Poor sleep
    • Difficulty concentrating
    • Hair loss or thinning
    • Weight-gain
    • Irregular menstrual cycles
    • Acne

*PCOS – Polycystic Ovarian Syndrome affects 6-10% of women. Though ovarian cysts may or may not be present, other symptoms are obesity, acne, infertility, irregular periods and hair growth on face, chest and back. Women with PCOS are often insulin resistant or type 2 diabetic. Testosterone levels are often higher than normal.

Warning:  Not for use during pregnancy or during lactation.

Like most dietary supplements, use of MigreLief+M should be discontinued one week before surgery to reduce the risk of excessive bleeding.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Side Effects

Potential side effects, though rare, can be:

1 – An individual being allergic to any of the ingredients in MigreLief+M. If you are allergic to any of the ingredients, cease taking the product.
2 – Some individuals may experience transient diarrhea when ingesting magnesium.
3 – Some individuals can experience gastro-intestinal upset when taking dietary supplements.
4 – Riboflavin (Vitamin B-2) can cause urine to become bright yellow. This is normal and harmless.
5 – Though rare, some people can feel achy, tired and experience a headache if they abruptly stop taking feverfew. It is recommended that you taper off gradually, cutting the dose down to one daily for a week, then down to one every other day for a week, and then stop.
6 – Like most dietary supplements, use of MigreLief should be discontinued one week before surgery to reduce the risk of excessive bleeding.

Warning:  Not for use during pregnancy or lactation.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


  1. Brown D, Gaby A, Reichert R. Clinical Applications of Natural Medicine–Migraine. NPRC Condition-Specific Monograph Series, 1997.
  2. Feverfew. Lawrence Review of Natural Products, September 1994.
  3. Awang DVC. Herbal Medicine, Feverfew. Canadian Pharm J 1989; 122:266-70.
  4. Heptinstall S, Awang DVC, Dawson BA, et al. Parthenolide Content and Bioactivity of Feverfew (Tanacetum parthenium). Estimation of Commercial and Authenticated Feverfew Products. J Pharm Pharmacol 1992; 44:391-5.
  5. Pugh WJ, Sambo K. Prostaglandin Synthetase Inhibitors in Feverfew. J Pharm Pharmacol 1988; 40-743-5.
  6. Heptinstall S, White A, Williamson L, Mitchell JRA. Extracts of Feverfew Inhibit Granule Secretion in Blood Platelets and Polymophonuclear Leukocytes. Lancet 1985; i:1071-4.
  7. Makheja AN, Bailey JM. A Platelet Phospholipase Inhibitor from the Medicinal Herb Feverfew (Tanacetum parthenium). Prostagland Leukotrienes Med 1982;8:653-60.
  8. Sumner H, Salan U, Knight DW, Hoult JRS. Inhibition of 5-Lipoxygenase and Cyclo-oxygenase in Leukocytes by Feverfew. Biochem Pharmacol 1992;43:2313-20.
  9. Johnson ES, Kadam NP, Hylands DM, Hylands PF. Efficacy of Feverfew As prophylactic Treatment of Migraine. British Med J 1985; 291:569-73.
  10. Murphy JJ. Heptinstall S, Mitchell JRA. Randomized Double-Blind Placebo-Controlled Trial of Feverfew in Migraine Prevention. Lancet 1988; ii:189-92.
  11. Altura BM. Calcium Antagonist Properties of Magnesium: Implications for Anti-migraine Actions. Magnesium 1985; 4:169-75.
  12. Ramadan NM, Halvorson H, Vande-Linde A, et al. Low Brain Magnesium in Migraine. Headache 1989; 29:590-93.
  13. Weaver K. Magnesium and Migraine. Headache 1990; 30:168.
  14. Faccinetti F, Sances G, Borella P, et al. Magnesium Prophylaxis of Menstrual Migraine: Effects on Intra-cellular Magnesium. Headache 1991; 31:298-304.
  15. Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of Migraine with Oral Magnesium: Results from a Prospective, Multi-Center, Placebo-Controlled and Double-Blind Randomized Study. Cephalalgia 1996; 16:257-63.
  16. Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the Prophylaxis of Migraine–A Double-Blind, Placebo-Controlled Study. Cephalalgia 1996;16:436-40.
  17. Schoenen J, Lenaerts M, Bastings E. High-dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study. Cephalalgia 1994l14:328-9
  18. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomised controlled trial. Neurology 1998; 50: 46670.
  19. Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhaupl KM, Arnold G. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol. 2004 Jul;11(7):475-7.
  20. Maria Condò1, Annio Posar1, Annalisa Arbizzani1 and Antonia Parmeggiani1 Riboflavin prophylaxis in pediatric and adolescent migraine. The Journal of Headache and Pain: Volume 10, Number 5 / October, 2009
  21. Schellenberg R. Treatment for PMS with agnus castus. BMJ. 2001 Han 20;322(7279):134-7
  22. Haut-und Gesch. 1964; 36:220 Giss, G. Rothenburg,W.
  23. Ther.Ggw 1967;106:124-6 Amann W. Improvement of acne vulgaris with Agnus castus
  24. Zbl GynSkol 1959 81:701 Bleier, W.
  25. Medica Emperica 1990, 9”494-502 Bohnert, K.J. Hahs, G. Phytotherapy in Gynecology and Obstetrics (Chasteberry) Acta
  26. J. clin. Biochem Nutr. 1993;14:211-218 Therapeutic evaluation of the effect of biotin on hyperglycemia in patients with non-insulin dependent diabetes mellitus.
  27. Headache.2007 Nov-Dec;47(10):1436-43 Insulin metabolism is altered in migraineurs. Cavestro, C. et al
  28. J Obstet Gynaecol 1990;97:847-52 vitamin B6 in the treatment of the premenstrual syndrome- a review, Kleijnen J. Riet GT et al
  29. Int J]. Gunn AD Vitam Nutr Res. 1985;Suppl 27:213–24 review
  30. J Int Med Res 1985;13:174-9 Controlled trial of B6 in PMS Harris RI, Deand BC
  31. Lancet 1985;1399 B6 and PMS Brush MG, Perry M.
  32. BMJ 1999;318;1375-81 Systematic Review B6 and PMS Dimmock PW et al
  33. Arch Dermatol 1974;110:130-131 B6 for premenstrual acne Snider B et al
  34. J Invest Dermatol 1942;5:143-8 B6 on resistant adolescent acne. Joliffe N et al
  35. Clin Neuropharmacol 30(1):25-38 Electrical mapping of the effect of theanine. Higgin BA et al
  36. Bio Psychol 74(1):39-45 Theanine reduces psychological and physiological stress Ozeki M et al.
  37. Biol Psychol 77(2):113-22 Effects of theanine and caffeine on cognition and mood Kimura k et al.


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